FORMULATION DEVELOPMENT AND EVALUATION OF POLYHERBAL GEL OF EFFECTIVE TREATMENT OF ACNE

The present research work deals with formulation and evaluation of herbal gels against this etiologic agent of acne vulgaris. Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. The crude extracts so obtained after the maceration process, each extracts were further concentrated on water bath evaporation the solvents completely to obtain the actual yield of extraction. To obtain the percentage yield of extraction is very important phenomenon in phytochemical extraction to evaluate the standard extraction efficiency for a particular plant, different parts of same plant or different solvents used. The extractive value of Embelia ribes, Acacia nilotica and Chenopodium album was found 6.98, 5.77, and 7.23% respectively. The prepared gel were evaluated for Psycho Rheological Characteristists, washability and Extrudability, spreadability, Determination of pH, Viscosity, and phenol content Formulations of gel the spreadibility ranging 9.25±2.10 to 13.25±1.25 the optimized formulation PHG4 is good (10.23±2.36). The formulation PHG4 has good viscosity 2545±11. The polyherbal gel obtained from plant used to suitably dilute upto the concentrations of 100, 50 and 25 microgram per ml and applied on to the test organism using well diffusion method.

Keywords: Viscosity, extrudability, rheology, drug content, extraction