SCREENING OF SOLVENT EXTRACTS OF CYCAS REVOLUTA FOR ISOLATION OF ANTIMICROBIAL COMPOUND

ABSTRACT

In the present investigation, the chloroformic and hydro-alcoholic extracts of leaves and female cones of Cycas revoluta were screened for its antimicrobial potential and in urge for isolation and characterization of the potent molecule responsible for antimicrobial potential against pathogenic and drug resistant strains. The results showed that both the leaves and female cones of Cycas revoluta are potent antimicrobial agents. It was found that chloroformic extracts of the cones was having potent antimicrobial activity in comparison to the chloroformic extracts of leaves. The studies report the isolation and characterization of a novel molecule, 2, 3-dihydro-4′-O-methyl-amentoflavone from the chloroformic extracts of leaves and female cones of the plant. The molecule was found to be promising antimicrobial agent against Methicillin resistant Staphylococcus aureus (MRSA), E. coli, Salmonella abony, Aspergillus niger, Candida albicans, and other pathogens reported in the study. The results hereby concluded that the extracts or the molecule can be utilized in formulating new antimicrobials which can be utilized in treating several infections caused by drug resistant pathogens. However further studies are however needed to study and evaluate its broad spectrum profile and to screen other different pharmacological activities.

Key words: Antimicrobial activity, Cycas revoluta, pathogenic and drug resistant strains, flavones

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