Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumorstroma crosstalk in experimental models

Lay summary
Little is known about the role of
post-translational modifications of
proteins in cholangiocarcinoma
development and progression.
Herein, we show that protein
NEDDylation is upregulated and
hyperactivated in cholangiocarcinoma,
promoting tumor
growth. Pharmacological inhibition
of NEDDylation halts cholangiocarcinogenesis
and could be
an effective therapeutic strategy to
tackle these tumors.