Published September 10, 2022 | Version v1
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Systematic Review and Pharmacological Potential of Hibiscus Rosa-Sinensis as Antidiabetic Drug

Creators

  • 1. Kashi Institute of Pharmacy
  • 2. Malti Memorial Trust CSM Group of Institutions
  • 3. Saraswati Devi Ram Sagar Jha College of Pharmacy

Description

The Hibiscus Rosa-Sinensis is a flower that has been used in traditional Chinese medicine for centuries. Recently, there has been renewed interest in the potential health benefits of this flower, particularly with regards to its Antidiabetic effects. A number of studies have shown that the extract from Hibiscus Rosa-Sinensis can help to lower blood sugar levels in people with diabetes mellitus, and it is thought that this may be due to the presence of certain compounds within the plant that have hypoglycemic activity. The exact mechanisms by which Hibiscus Rosa-Sinensis lowers blood sugar levels are not fully understood at present, but it is thought that it may work by stimulating insulin secretion from the pancreas or by improving glucose tolerance.

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References

  • Bhaskar, A., Nithya, V., & Vidhya, V. G. (2021). Phytochemical screening and in vitro antioxidant activities of the ethanolic extract of Hibiscus rosa sinensis L.
  • Mehmood, F., Shahzadi, I., Waseem, S., Mirza, B., Ahmed, I., & Waheed, M. T. (2020). Chloroplast genome of Hibiscus rosa-sinensis (Malvaceae): comparative analyses and identification of mutational hotspots. Genomics, 112(1), 581-591.
  • Abd El-Kader, M. F. H., Elabbasy, M. T., Adeboye, A. A., Zeariya, M. G., & Menazea, A. A. (2021). Morphological, structural and antibacterial behavior of eco-friendly of ZnO/TiO2 nanocomposite synthesized via Hibiscus rosa-sinensis extract. Journal of materials research and technology, 15, 2213-2220.
  • Rengarajan, S., Melanathuru, V., Govindasamy, C., Chinnadurai, V., & Elsadek, M. F. (2020). Antioxidant activity of flavonoid compounds isolated from the petals of Hibiscus rosa sinensis. Journal of King Saud University-Science, 32(3), 2236-2242.
  • Olmedo-Velarde, A., Hu, J., & Melzer, M. J. (2021). A virus infecting hibiscus rosa-sinensis represents an evolutionary link between cileviruses and higreviruses. Frontiers in microbiology, 12, 660237.
  • Buarki, F., AbuHassan, H., Al Hannan, F., & Henari, F. Z. (2022). Green Synthesis of Iron Oxide Nanoparticles Using Hibiscus rosa sinensis Flowers and Their Antibacterial Activity. Journal of Nanotechnology, 2022.
  • Park HJ, Lee J, Kim MJ, Kang TJ, Jeong Y, Um SH, Cho SW. Sonic hedgehog intradermal gene therapy using a biodegradable poly(β-amino esters) nanoparticle to enhance wound healing. Biomaterials. 2012; 33(35):9148-56.
  • Razack, S. A., Suresh, A., Sriram, S., Ramakrishnan, G., Sadanandham, S., Veerasamy, M., ... & Sahadevan, R. (2020). Green synthesis of iron oxide nanoparticles using Hibiscus rosa-sinensis for fortifying wheat biscuits. SN Applied Sciences, 2(5), 1-9.
  • Nasrollahzadeh, M., Bidgoli, N. S. S., Issaabadi, Z., Ghavamifar, Z., Baran, T., & Luque, R. (2020). Hibiscus Rosasinensis L. aqueous extract-assisted valorization of lignin: preparation of magnetically reusable Pd NPs@ Fe3O4-lignin for Cr (VI) reduction and Suzuki-Miyaura reaction in eco-friendly media. International journal of biological macromolecules, 148, 265-275.
  • British Pharmacopoeia, 1993. The British Pharmacopoeia. Vol. 1, HMSO Publication Center, London, pp: 604-605.
  • Dinesh, G. K., Pramod, M., & Chakma, S. (2020). Sonochemical synthesis of amphoteric Cu0-Nanoparticles using Hibiscus rosa-sinensis extract and their applications for degradation of 5-fluorouracil and lovastatin drugs. Journal of Hazardous Materials, 399, 123035.
  • Elemike, E. E., Onwudiwe, D. C., & Mbonu, J. I. (2021). Facile synthesis of cellulose–ZnO-hybrid nanocomposite using Hibiscus rosa-sinensis leaf extract and their antibacterial activities. Applied Nanoscience, 11(4), 1349-1358.
  • Yang, X., Rajivgandhi, G. N., Ramachandran, G., Alharbi, N. S., Kadaikunnan, S., Khaled, J. M., ... & Manoharan, N. (2020). Preparative HPLC fraction of Hibiscus rosa-sinensis essential oil against biofilm forming Klebsiella pneumoniae. Saudi Journal of Biological Sciences, 27(10), 2853-2862.
  • Lingesh, A. M. P. K., Paul, D., Naidu, V. G. M., & Satheeshkumar, N. (2019). AMPK activating and anti adipogenic potential of Hibiscus rosa sinensis flower in 3T3-L1 cells. Journal of ethnopharmacology, 233, 123-130.
  • Lingesh, A. M. P. K., Paul, D., Naidu, V. G. M., & Satheeshkumar, N. (2019). AMPK activating and anti adipogenic potential of Hibiscus rosa sinensis flower in 3T3-L1 cells. Journal of ethnopharmacology, 233, 123-130.
  • Vijayakumar, S. A. U. M. Y. J. E. A. U. A. P. A. U. P. P. K., Yabesh, J. M., Arulmozhi, P., & Praseetha, P. K. (2018). Identification and isolation of antimicrobial compounds from the flower extract of Hibiscus rosa-sinensis L: In silico and in vitro approaches. Microbial pathogenesis, 123, 527-535.
  • Zahed, M., Jafari, D., & Esfandyari, M. (2020). Adsorption of formaldehyde from aqueous solution using activated carbon prepared from Hibiscus rosa-sinensis. International Journal of Environmental Analytical Chemistry, 1-23.
  • Jusoh, Y. M. M., Idris, A. A., Khairuddin, N., Zaidel, D. N. A., Hashim, Z., Mahmooda, N. A. N., ... & Muhamad, I. I. (2018). Effect of solvent pH, microwave power and extraction time on microwave-assisted extraction of Hibiscus rosa-sinensis. Chemical Engineering Transactions, 63, 541-546.
  • Gandhi, S. P., Lokhande, K. B., Swamy, V. K., Nanda, R. K., & Chitlange, S. S. (2019). Computational data of phytoconstituents from Hibiscus rosa-sinensis on various anti-obesity targets. Data in brief, 24, 103994.
  • Othman, M., Yusup, A. A., Zakaria, N., & Khalid, K. (2018, July). Bio-polymer chitosan and corn starch with extract of hibiscus rosa-sinensis (hibiscus) as PH indicator for visually-smart food packaging. In AIP Conference Proceedings (Vol. 1985, No. 1, p. 050004). AIP Publishing LLC.
  • Ghodoum Parizipour, M. H., & Keshavarz-Tohid, V. (2020). Identification and phylogenetic analysis of a tobamovirus causing hibiscus (Hibiscus rosa-sinensis L.) mosaic disease in Iran. Journal of Plant Pathology, 102(3), 813-824
  • Hazarika, H. N., & Khanikor, B. (2022). Habitat wise distribution of ants with special reference to their host plants in Kholahat Reserve Forest, Assam, India.
  • Mall, S., Pandey, V., Srivastava, A., & Gaur, R. K. (2021). Detection and Characterization of Plant Viruses Infecting Hibiscus rosa-sinensis L. In Virus Diseases of Ornamental Plants (pp. 151-164). Springer, Singapore.
  • HUANG, X., QIN, L., HUANG, L., LU, Y., LUO, E., HUANG, L., & LIU, Y. (2020). Variation Characteristics of Drought and Rehydration on the Growth of Hibiscus rosa-sinensis Linn. and Soil Microbial Diversity in Rhizosphere. Chinese Journal of Tropical Crops, 41(2), 401.
  • Ahmed, M. A., & Shahin, S. M. (2022). THE ROLE OF SALICYLIC ACID IN REDUCING WATER REQUIREMENTS FOR HIBISCUS ROSA-SINENSIS L. PLANT. Scientific Journal of Flowers and Ornamental Plants, 9(1), 13-25.
  • Magdalita, P. M., & San Pascual, A. O. (2022). Hibiscus (Hibiscus rosa-sinensis): Importance and Classification. In Floriculture and Ornamental Plants (pp. 483-522). Singapore: Springer Nature Singapore.
  • Subramanian, K., Vadivu, K. S., Subramaniyam, L., & Kumar, M. D. (2022). Synthesis, characterization, and analysis of bioplasticizer derived from Hibiscus rosa-sinensis leaves and cinnamon bark for poly (vinyl chloride) films. Industrial Crops and Products, 182, 114933.
  • Suseno, R., & Nizori, A. (2021, August). Development of Functional Drink Using Hibiscus rosa-sinensis Leaves. In The 3rd Green Development International Conference (GDIC 2020) (pp. 11-14). Atlantis Press.
  • Lingesh, A. M. P. K., Paul, D., Naidu, V. G. M., & Satheeshkumar, N. (2019). AMPK activating and anti adipogenic potential of Hibiscus rosa sinensis flower in 3T3-L1 cells. Journal of ethnopharmacology, 233, 123-130.
  • Rajendran, A., Siva, E., Dhanraj, C., & Senthilkumar, S. (2018). A green and facile approach for the synthesis copper oxide nanoparticles using Hibiscus rosa-sinensis flower extracts and it's antibacterial activities. J Bioprocess Biotech, 8(3), 324.
  • Al-Snafi, A. E. (2018). Chemical constituents, pharmacological effects and therapeutic importance of Hibiscus rosa-sinensis-A review. IOSR Journal of Pharmacy, 8(7), 101-119.
  • Buarki, F., AbuHassan, H., Al Hannan, F., & Henari, F. Z. (2022). Green Synthesis of Iron Oxide Nanoparticles Using Hibiscus rosa sinensis Flowers and Their Antibacterial Activity. Journal of Nanotechnology, 2022.
  • Ngan, L. T. M., Tan, M. T., Hoang, N. V. M., Thanh, D. T., Linh, N. T. T., Hoa, T. T. H., ... & Hieu, T. T. (2021). Antibacterial activity of Hibiscus rosa-sinensis L. red flower against antibiotic-resistant strains of Helicobacter pylori and identification of the flower constituents. Brazilian Journal of Medical and Biological Research, 54.
  • Mehta, J., & Iffet, A. (2020). Analysis of Phytochemicals, Antibacterial and Antioxidant Activities of Certain MEDICINAL Plants of Garhwal Against Human Pathogens. International Journal of Bio-Technology and Research (IJBTR), 10, 49-62.
  • Priya, K., & Sharma, H. P. Phytochemical analysis and antimicrobial activity of Hibiscus Rosa Sinensis.
  • Rengarajan, S., Melanathuru, V., Govindasamy, C., Chinnadurai, V., & Elsadek, M. F. (2020). Antioxidant activity of flavonoid compounds isolated from the petals of Hibiscus rosa sinensis. Journal of King Saud University-Science, 32(3), 2236-2242.
  • Bhaskar, A., Nithya, V., & Vidhya, V. G. (2021). Phytochemical screening and in vitro antioxidant activities of the ethanolic extract of Hibiscus rosa sinensis L.
  • Cruz Hernández, A., Hernández Sanchez, D., Gómez-Vázquez, A., Govea-Luciano, A., Pinos-Rodríguez, J. M., Álvarez González, C. A., ... & Brito Vega, H. (2019). Tannin concentration and degradation rate in vitro of Morus alba and Hibiscus rosa-sinensis. Acta universitaria, 29.
  • Jasiem, T. M., Nasser, N. M., Baderden, S. K., & Hasan, H. A. (2019, August). Pharmacognostical and phytochemical studies of Iraqi Hibiscus rosa-sinensis. In AIP Conference proceedings (Vol. 2144, No. 1, p. 040002). AIP Publishing LLC.
  • Kalpana, V. N. S., Mary, J., Mini, S., Soumya, N. P. P., & Mondal, S. (2021). Hibiscus rosa sinensis L. anthocyanins prevent lipid peroxidation and improve antioxidant status in the liver of streptozotocin-induced diabetic rats. Bioactive Compounds in Health and Disease, 4(10), 240-255.
  • Sri Raghavi, R., Visalakshi, M., Karthikeyan, S., Amutha Selvi, G., Thamaraiselvi, S. P., & Gurusamy, K. (2022). Standardisation of anthocyanin extraction techniques from hibiscus (Hibiscus rosa-sinensis) petals for biocolour utilisation.
  • Cole, J. B., & Florez, J. C. (2020). Genetics of diabetes mellitus and diabetes complications. Nature reviews nephrology, 16(7), 377-390.
  • Khan, R. M. M., Chua, Z. J. Y., Tan, J. C., Yang, Y., Liao, Z., & Zhao, Y. (2019). From pre-diabetes to diabetes: diagnosis, treatments and translational research. Medicina, 55(9), 546.
  • Khan, R. M. M., Chua, Z. J. Y., Tan, J. C., Yang, Y., Liao, Z., & Zhao, Y. (2019). From pre-diabetes to diabetes: diagnosis, treatments and translational research. Medicina, 55(9), 546.
  • Williams, R., Karuranga, S., Malanda, B., Saeedi, P., Basit, A., Besançon, S., ... & Colagiuri, S. (2020). Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas. Diabetes research and clinical practice, 162, 108072.
  • Hasan, M. K., Alam, M. A., Das, D., Hossain, E., & Hasan, M. (2020). Diabetes prediction using ensembling of different machine learning classifiers. IEEE Access, 8, 76516-76531.
  • Boscari, F., & Avogaro, A. (2021). Current treatment options and challenges in patients with Type 1 diabetes: Pharmacological, technical advances and future perspectives. Reviews in Endocrine and Metabolic Disorders, 22(2), 217-240.
  • Khursheed, R., Singh, S. K., Wadhwa, S., Kapoor, B., Gulati, M., Kumar, R., ... & Dua, K. (2019). Treatment strategies against diabetes: Success so far and challenges ahead. European journal of pharmacology, 862, 172625.
  • Pathak, V., Pathak, N. M., O'Neill, C. L., Guduric-Fuchs, J., & Medina, R. J. (2019). Therapies for type 1 diabetes: current scenario and future perspectives. Clinical Medicine Insights: Endocrinology and Diabetes, 12, 1179551419844521.
  • Rudland, V. L. (2019). Diagnosis and management of glucokinase monogenic diabetes in pregnancy: current perspectives. Diabetes, metabolic syndrome and obesity: targets and therapy, 12, 1081.
  • Amjad, S., Jafri, A., Sharma, A. K., & Serajuddin, M. (2019). A novel strategy of nanotized herbal drugs and their delivery in the treatment of diabetes: Present status and future prospects. Journal of Herbal Medicine, 17, 100279.
  • Thakur, A. K., Tyagi, S., & Shekhar, N. (2019). Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs. Translational Medicine Communications, 4(1), 1-13.
  • Rahman, M. M., Islam, M. R., Shohag, S., Hossain, M. E., Rahaman, M. S., Islam, F., ... & Cavalu, S. (2022). The multifunctional role of herbal products in the management of diabetes and obesity: a comprehensive review. Molecules, 27(5), 1713.
  • Banerjee, M., Khursheed, R., Yadav, A. K., Singh, S. K., Gulati, M., Pandey, D. K., ... & Pandey, N. K. (2020). A systematic review on synthetic drugs and phytopharmaceuticals used to manage diabetes. Current Diabetes Reviews, 16(4), 340-356.
  • Shanmugam, K. R., Shanmugam, B., Subbaiah, G. V., Ravi, S., & Reddy, K. S. (2021). Medicinal plants and bioactive compounds for diabetes management: important advances in drug discovery. Current Pharmaceutical Design, 27(6), 763-774.
  • Ozturk, M., Altay, V., Latiff, A., Asad Ziaee, M., Iqbal Choudhry, M., Shaheen, F., & Durmuşkahya, C. (2018). A comparative analysis of the medicinal plants used for diabetes mellitus in the traditional medicine in Turkey, Pakistan, and Malaysia. In Plant and Human Health, Volume 1 (pp. 409-461). Springer, Cham.
  • Naceiri Mrabti, H., Bouyahya, A., Naceiri Mrabti, N., Jaradat, N., Doudach, L., & Faouzi, M. E. A. (2021). Ethnobotanical survey of medicinal plants used by traditional healers to treat diabetes in the Taza region of Morocco. Evidence-Based Complementary and Alternative Medicine, 2021.
  • Kasole, R., Martin, H. D., & Kimiywe, J. (2019). Traditional medicine and its role in the management of diabetes mellitus:"patients' and herbalists' perspectives". Evidence-Based Complementary and Alternative Medicine, 2019.
  • Husna, F., Suyatna, F. D., Arozal, W., & Poerwaningsih, E. H. (2018). Anti-diabetic potential of Murraya koenigii (L.) and its antioxidant capacity in nicotinamide-streptozotocin induced diabetic rats. Drug Research, 68(11), 631-636.
  • Pillai, S. S., & Mini, S. (2018). Attenuation of high glucose induced apoptotic and inflammatory signaling pathways in RIN-m5F pancreatic β cell lines by Hibiscus rosa sinensis L. petals and its phytoconstituents. Journal of ethnopharmacology, 227, 8-17.
  • Ndarubu, T. A., Chiamaka, O. S., Alfa, S., Aishatu, M., Chinedu, O. E., Wenawo, D. L., ... & Eustace, B. B. (2019). Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats. GSC Biological and Pharmaceutical Sciences, 8(3).
  • Sharmin, R., Joarder, H. H., Alamgir, M., Mostofa, G., & Islam, M. (2018). Antidiabetic and hepatoprotective activities of Bombax ceiba young roots in alloxan-induced diabetic mice. J Nutrition Health Food Sci, 6, 1-7.
  • Oladoja, F., Irokosu, E., Kale, O., & Olubodun-Obadun, T. (2021). Antidiabetic and Antioxidant Activities of Extract of Entandrophragma Cylindricum (Sprague) Leaves in Male Wistar Rats. Journal of Research in Applied and Basic Medical Sciences, 7(3), 108-121.
  • Ansari, P., Azam, S., Hannan, J. M. A., Flatt, P. R., & Wahab, Y. H. A. (2020). Anti-hyperglycaemic activity of H. rosa-sinensis leaves is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of insulin secretion. Journal of ethnopharmacology, 253, 112647.