FORMULATION AND EVALUATION OF PANTOPRAZOLE SODIUM ENTERIC COATED TABLETS USING DIFFERENT SUPER DISINTEGRANTS

The aim of the present study is to formulate and evaluate the pantoprazole sodium enteric coated tablets using different super-disintegrants in different ratio’s and to study the physicochemical properties, drug-excipients compatibility studies and to carry out disintegration, dissolution and stability studies. Pantoprazole is a proton pump inhibitor belongs togroup of benzimidazole. This compound inhibits gastric acid formation and thereby it is very efficientfor the treatment of gastric and duodenum ulcers. An enteric coated pantoprazole sodiumtablets were successfully prepared by directcompression method. Nine formulations ofPantoprazole were developed by preparing coretablets using mannitol as diluent, Aerosil as glidant,Magnesium stearate as lubricant, PVPK30 as binderandkollidone, HPC &Explotab as super disintegrants in 3 different concentrations i.e. 5%7.5%, 10% of which F3 formulation with kollidoneas super disintegrant with concentration of 10% wasselected as best formulation as it has shownmaximum drug release of 100.16% within 45 mins.

Key words: Pantoprazole, Formulation, Evaluation, Enteric coated tablets