Assessment of ovarian reserve and role of its determining factors in patients with endometriomas combined with pelvic inflammatory disease

Bihun R. V., Henyk N. I. Assessment of ovarian reserve and role of its determining factors in patients with endometriomas combined with pelvic inflammatory disease. Journal of Education, Health and Sport. 2022;12(4):259-270. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.04.020

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.04.020

https://zenodo.org/record/7023222

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

 © The Authors 2022;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Received: 23.03.2022. Revised: 04.04.2022. Accepted: 29.04.2022.

ASSESSMENT OF OVARIAN RESERVE AND ROLE OF ITS DETERMINING FACTORS IN PATIENTS WITH ENDOMETRIOMAS COMBINED WITH PELVIC INFLAMMATORY DISEASE

R. V. Bihun, N. I. Henyk

Ivano-Frankivsk National Medical University,

Department of Obstetrics and Gynecology named after I. D. Lanovyi

Abstract

Resume. Endometriosis affects from 10% to 50% of women of reproductive age and is one of the most common diseases in gynecology. One of its most common kinds – ovarian endometrial cysts – accounts from 17% to 44% of all patients. The aim of the study was to evaluate the parameters of the ovarian reserve in patients with endometriomas combined with pelvic inflammatory disease. Research materials and methods. Two groups of patients were formed: group I included 45 women with endometriomas combined with pelvic inflammatory disease; group II consisted of 45 patients with isolated endometriomas. Generally accepted criteria were used to assess the ovarian reserve: FSH level, AMH > 1.0 n/ml, number of follicles D, volume of both ovaries. Statistical calculations included the method of calculating the odds ratio (OR) and its 95% confidental interval (95% CI).

Research results and their discussion. The frequency of the decrease in main parameters of the ovarian reserve showed a deviation in two-thirds of cases in women of group I (68.9%), which is 2.2 times more common (p<0.05). AMH parameters showed a deviation by 3.6 times compared to the control group, and by 1.7 times compared to the parameters of group II (p<0.05). The average level of FSH in blood serum of women in group I was 2.0 times higher than the control indicators, and 1.5 times higher than the indicators of patients in group II. The number of antral follicles < 5 in group II was in 22.2% of observations; and in group 1 – in 91.1% (p<0.05). The endometrioma itself demonstrated a significant influence on the parameters of the ovarian reserve: in the case of a significant share of multiple bilateral endometrial cysts (OR=5.65; 95% CI: (1.71-18.67); p<0.05), their large sizes (OR=7.94; 95% CI: (3.0-21.0); p<0.05), combination with pelvic inflammatory disease, (OR=29.42; 95% CI: (6.33 -146.72); p<0.05) and tubo-ovarian tumours (OR=6.96; 95% CI: (1.44-33.51); p<0.05), as well as aggressive consequences during surgical intervention on both ovaries (OR=8.26; 95% CI: (2.65-25.79); p<0.05). Conclusions. About half of the patients with endometriomas combined with pelvic inflammatory disease note a decrease in the ovarian reserve. Statistically reliable factors are multiple and large ovarian endometrial cysts, a combination with recurrent pelvic inflammatory disease, tubo-ovarian tumours and surgical interventions on the ovaries.

Key words: endometrioma; pelvic inflammatory disease; ovarian reserve.