FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF TERBUTALIINE SULFATE

The outcome of present work provides a concrete basis for development of fast dissolving tablets of Terbutaline sulphate. Various approaches explored in the present work can be applied to achieve quick disintegration, good mouth feel and adequate mechanical strength, which improve patient compliance. Further work can be focused on co processing of various diluents with superdisintegrant. Some herbal superdisintegrant in freeze dried form can be investigated to determine their effect on disintegration time and hardness. To evaluate the effects of fast dissolving tablets in stress conditions, pharmacokinetic study can be performed in diseased state, and to compare with the results obtained in non- diseased state. All the researchers working on Terbutaline sulphate concentrates their research on the disintegration behavior of the tablets using super disintegrants which does not full fill the basic requirements of the mouth dissolving tablets i.e. patient compliance. Industries who want to make a Terbutaline sulphate blindly incorporating insoluble taste masking resins, superdisintegrants for disintegration and trading as mouth dissolving tablet. Due to lots of limitations like hardness, mechanical strength, no ease of manufacturing and most important cost of manufacturing, that’s why, industries concentrate whole emphasis on the use of superdisintegrants and make researchers not to work on mouth dissolving tablets instead moves on to mouth disintegrating tablets. Thus we concentrate on formulating mouth dissolving tablets giving complete dissolution of the formulation with minimum residue.

KEYWORDS- Terbutaline sulphate, Migraine, Mouth Dissolving Tablet, Croscarmellose Sodium, Crospovidone, Superdisintegrants.