THE ROLE AND TREATMENT OF TESTOSTERONE IN MEN WITH TYPE 2 DIABETES

Abstract. Epidemiological studies consistently demonstrate that low serum testosterone is not only common in men with established type 2 diabetes, but also predicts future diabetes risks and increased mortality. Preclinical studies report plausible mechanisms by which low testosterone may mediate dysglycemia. Treatment with exogenous testosterone consistently reduces fat mass, increases muscle mass, and improves insulin resistance. Large, well-designed clinical trials are needed, given that the benefit/risk balance of testosterone treatment is not well understood.