Prevalence of high-level aminoglycoside and vancomycin-resistant enterococcus species at a tertiary care hospital in greater noida, u.p

Author: 

Reshu Chauhan., Tarana Sarwat and Dalip K Kakru

Background: Enterococcal infection has emerged as a major therapeutic challenge. Exposure of High- Level Aminoglycoside Resistance (HLAR) and Vancomycin-Resistant among Enterococcus species has further limited the drug in Enterococcal infections.
Objective: To estimate the prevalence of High- Level Aminoglycoside Resistant (HLAR), i.e HLG and HLS resistance and Vancomycin-Resistant among Enterococcus species at a tertiary care hospital in Greater Noida.
Material & Methods: A total of 80 isolates identified by morphological and biochemical characteristics were tested for antibiotic susceptibility using Kirby- Bauer disc diffusion method and the Epsilometer test (E- test) and Vitek automated as per standard protocol.
Results: Eighty out of 13,639 culture-positive clinical samples comprising of 48 urine, 15 from pus, 6 blood, 5 vaginal swabs, 2 ETT, 1 BAL, and 1 tissue fluid(Pleural fluid) isolates were identified as Enterococcus faecalis (57.5%), Enterococcus faecium (35%), Enterococcus durans (5%), and Enterococcus gallinarum (2.5%). The majority of the isolates (61.25%) were from a urine specimen. While High-Level Aminoglycoside Resistance was seen in 71.62% of the isolates. Vancomycin-Resistant Enterococci were found to be majorly in urine isolates.
Conclusions: The petrifying rise in the prevalence of Vancomycin and multidrug resistance strains authorize immediate, sufficient, and efficient surveillance programs to prevent and control its spread.