Poster Open Access

A Click Chemistry Approach to cis-Platinum(II)-TFO Targeted DNA Crosslinking

Hennessy, Joseph; Coche, Malou; McGormann, Brionna; Farrell, Nicholas P.; Brown, Tom; Kellett, Andrew

Therapies that target the downstream inhibition of gene expression are of great current research significance with considerable efforts now dedicated to the discovery of new antisense oligonucleotides (ASOs). The development of nucleic acid probes targeting DNA, such as triplex-forming oligonucleotides (TFOs), offers an alternative strategy whereby gene expression is directly inhibited at the genomic level. Here, we present a click chemistry strategy for the generation of a new class of cis-platinum(II)-TFO hybrid biomaterial that possess DNA binding and crosslinking activity.

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Publication date:
June 6, 2022
DOI:
10.5281/zenodo.6908067

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10.5281/zenodo.6908067

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Grants:
European Commission:
  • NATURE-ETN - Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification (861381)
Meeting:
XVIIIth Symposium on Chemistry of Nucleic Acid Components (SCNAC), Cesky Krumlov, Czechia, 6 June 2022
License (for files):
Creative Commons Attribution 4.0 International

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