Published July 8, 2022 | Version v1
Poster Open

Crystallization and structural characterization of triplexes and triplexligand systems using DNA X-ray crystallography

Description

The DNA triplex can be formed by the introduction of a triplex-forming oligonucleotide (TFO) to a DNA duplex. Here we show results describing the behaviour of triple helical molecules in UV-visible and circular dichroism spectroscopy. Additionally, we present the DNA structure obtained with X-Ray crystallography of a dsDNA belonging to a studied triplex DNA system.

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Poster_NAF220704.pdf

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Funding

NATURE-ETN – Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification 861381
European Commission