Published July 15, 2022
| Version v1
Journal article
Open
Structural features affecting the selectivity of LAT1-targeted phenylalanine drug conjugates
Description
This file contains favorable docking poses of a series of compounds to the Large neutral Amino acid Transporter 1 (LAT1). The compounds were docked to the cryo-electron microscopy structure of LAT1 (Protein Data Bank ID: 6IRT). The data have been generated by induced-fit docking using the Schrödinger maestro suite 2021-04. For data visualization, Schrödinger maestro suite 2022-02 was utilized.
Notes
Other foundations which support our research include: Orion Research Foundation, and The Finnish Pharmaceutical Society.
Files
Files
(4.7 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:04e260c69fe9e8798be7370d6747f6bb
|
4.7 MB | Download |