MORPHOLOGICAL SUBSTANTIATION OF THE EFFECTIVENESS OF PHOTODYNAMIC THERAPY FOR WIDESPREAD PERITONITIS IN THE EXPERIMENT

The article presents the results of experimental studies to study the effect on the parietal and visceral peritoneum of intact animals and with simulated widespread peritonitis on white outbred rats weighing 140-180 g. It was found that methylene blue at a concentration of 0.05% in intact animals after exposure for 5 minutes causes desquamation and small foci of necrosis of mesothelial cells, and with peritonitis against the background of photodynamic therapy, it has a beneficial effect on reparative processes in connection with the formation of singlet oxygen.

The histological picture of the peritoneum in rats after the sanitation of the abdominal cavity by PDT at all stages of the study was qualitatively better than in the representatives of the group during the sanitation of the abdominal cavity with 0.02% chlorhexidine solution. The authors, on the basis of the results of morphological studies, recommend the developed method of photodynamic sanitation of the abdominal cavity to be introduced into clinical practice.