Journal article Open Access
Synthesis, Characterization and Biological Evaluation of Some 1,3,4-oxadiazole Incorporated Coumarin Derivatives as Antifungal Agents
Muhammad Abul Kashem Liton; Md. Sajid Hasan; Sabrina Helen; Mukta Das; Md. Shalauddin
ABSTRACT
Coumarins are the family of benzopyrones, in which benzene ring amalgamated with the pyrone ring. Their versatile oxygen-containing heterocyclic structure and physicochemical characteristics are responsible to attract great attention from medicinal chemists and pharmacologists and for being a privileged scaffold in medicinal chemistry. In this study, 1, 3, 4 -oxadiazole incorporated a series of new coumarin derivatives have been synthesized. Structures of the newly synthesized compounds were established on the basis of FT-IR, 1H NMR spectroscopic techniques and elemental analysis. The synthesized compounds were screened for their in vitro antifungal activity against five pathogenic fungal strains: Aspergillus niger, Penicillium notatum, Saccharomyces cerevisiae, Penicillium chrysogenum and Neurospora crassa by disk-diffusion method. All the compounds were found to have significant antifungal activity against all the fungal strains.
Keywords: Coumarins, 1,3,4-oxadiazole, Antifungal Activity.
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- Publication date:
- April 1, 2022
- DOI:
-
- Keyword(s):
- Coumarins, 1,3,4-oxadiazole, Antifungal Activity.
- Published in:
- AMERICAN JOURNAL OF PHARMTECH RESEARCH: 12 pp. 61-70 (2).
- License (for files):
- Creative Commons Attribution 4.0 International