FORMULATION OF FLURBIPROFEN LOADED NANOSTRUCTURED LIPID CARRIERS OF FLURBIPROFEN

Nanostructured lipid carriers (NLCs) are recently invented second-generation lipidic carriers. Flurbiprofen exhibits poor cutaneous bioavailability and systemic side effects on topical administration, so there is an unmet need for a novel carrier and its optimized therapy. The aim of present work to develop flurbiprofen loaded Nanostructured lipid carriers gel for effective treatment of topical disease. The Entrapment efficiency of formulation F1 to F16 were found to be 60.66±0.60 to 78.51±0.25 respectively. The maximum entrapment efficiency was found in formulation F16 (88.76±0.44). The Drug content of formulation F16 was also found high in formulation F16 select as optimized formulation. The prepared gel at least rpm of 10 exhibited a viscosity of 3145±11 to 3145±11cps that indicates that the formulation has the desired viscosity required for semisolid formulation for proper packaging. It was found that the viscosity decreases as the rotational speed of viscometer increased suggesting that greater the shearing the lower viscosity favours easy spreadability further confirmed by spreadability and rheological testing. When the regression coefficient values of were compared, it was observed that ‘r²’ values of First Order was maximum i.e. 0.955 hence indicating drug release from formulations was found to follow First Order.

Keywords: Flurbiprofen, Nanostructured lipid carriers, Formulation, Evaluation