EXCISION AND INCISION WOUND HEALING ACTIVITY OF DIFFERENT EXTRACT OF VITEX TRIFOLIA L IN ALBINO RATS.

Wound healing is the process of repair that follows injury to the skin and other soft tissues. Following injury, an inflammatory response occurs and the cells below the dermis (the deepest skin layer) begin to increase collagen (connective tissue) production. Later, the epithelial tissue (the outer skin) is regenerated. There are three stages to the process of wound healing: inflammation, proliferation, and remodeling. Traditionally, Vitex trifolia L is used for wound healing. Since no detailed scientific data are available regarding the wound-healing activity of Vitex trifolia L is the present study was designed to explore the same. The wound-healing efficacy of petroleum ether, chloroform, ethyl acetate, ethanol and aqueous extract of Vitex trifolia L is was evaluated in excision and incision wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, and tensile strength of incision wound. Student's t test was used to analyze the results obtained from the present study and P<0.05 was considered significant. Ethyl Acetate extract of Vitex trifolia was found to possess significant wound-healing activity, which was evidenced by decrease in the period of epithelialization, increase in the rate of wound closer and skin-breaking strength. The present study has demonstrated that the Ethyl Acetate extract of Vitex trifolia has properties that render them capable of promoting accelerated wound-healing activity compared with placebo control.

Keywords: Vitex trifolia, wound healing, inflammation, proliferation, remodeling, Ethyl Acetate.