THE PAEDS GUIDELINE FOR HOSPITAL BASED CEREBRAL PALSY MONITORING IN LAHORE: A STUDY TO DEVELOP A HOSPITAL BASED MONITORING PROCESS IN PAKISTAN

Aim: Pakistan saw a record number of influenza reports in 2021. In the setting of a restricted publicly funded vaccination campaign, two monitoring studies were integrated to describe the demography of hospitalized influenza in adolescents and reflect on vaccine efficacy.

Methods: Participants were recruited in advance (June 2020–May 2021). Youth aged 15 years was hospitalized in 10 hospitals in Lahore having severe respiratory disease and laboratory-confirmed influenza. Subjects have been admitted to the hospital having acute respiratory infections but tested negative for influenza. The test-negative approach was used to calculate VE estimations.

Results: The overall 1276 offspring remained hospitalized having influenza: 32.6 percent remained under the age of three, 9.4 percent have been indigenous, and 46.2 percent had comorbid illnesses that made serious influenza more likely. Influenza B was found in 35.2 percent of the samples, whereas influenza A/H1N1 and A/H3N2 were found in 48.3 percent and 53.9 percent of the subtyped influenza A specimens, respectively. The average length of stay remained four days, with 15.6 percent admitted to intensive care unit and 16.8 percent receiving oseltamivir. Four in-hospital fatalities (0.4 percent) happened, one of which was thought to be influenza-related. Only 18.2 percent of the test-negative panels received immunization. The VE of an inactivated quadrivalent influenza vaccine was reported calculated to be 31.4 percent (96 percent confidence range, 3.7 percent –51.3 percent).

Conclusion: In Lahore, substantial influenza-related mortality was seen in 2021. The majority of hospitalized youngsters did not have any comorbid conditions. Vaccine coverage and antiviral usage were insufficient. Although the influenza vaccination was effective in 2021, the VE was lesser than in prior seasons. In 2019, many Australian states financed preschool immunization programs. More measures are necessary to promote immunization and assess its efficacy.

Keywords: Influenza Reports, Publicly Funded Vaccination Campaign, Hospital-Based, Lahore, Pakistan.