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Published June 5, 2022 | Version v1
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PHARMACOLOGY OF HEMIDESMUS INDICUS FOR VARIOUS CNS ACTIVITIES

Description

The aqueous and ethanolic extracts of the plants viz., H. indicus (Stem & Leaves) and L. camara (Stem & Flowers) were evaluated for various CNS activity viz., anti-inflammatory activity, analgesic activity, antipyretic activity, central muscle relaxant property, anti- convulsant activity, CNS stimulant or depressant activity, anxiolytic activity and sedative- hypnotics activity in different animal models. The results obtained indicate that the extracts found to have significant (P < 0.05). Aqueous extracts at test doses 400 mg/kg body weight was found to be more effective in all most all of the biological activity screened in compared to other extracts at different dose and standard drug. Furthermore, all these activities of CNS are due to the presence of alkaloids, terpenoids and tannins which was also confirmed in preliminary phytochemical screening of the extracts of both plants.

Hence, it was proved and concluded from the present research work that Both Plant extracts were found satisfactory potent for CNS activities viz. to viz., analgesic effect, antipyretic effect, anti-inflammatory effect, central muscle relaxant property, anti-convulsant effect,

CNS depressant effect, anxiolytic effect and sedative-hypnotics effect in proper respective animal models.

Moreover, the test dose of 400 mg/kg has promising effects than other test doses in aqueous and ethanolic extracts of both plant parts.

Keywords: indigenous, native, Unani Ayurveda, medicine, irremediable resources, Analgesic, medial dose, micrometric, morphological, parametere

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