FORMULATION DEVELOPMENT AND EVALUATION OF ETODOLAC EMULGEL WITH NATURAL PENETRATION ENHANCER

The purpose of this research was to prepare etodolac loaded emulsion for sustained release of drug and incorporate it in to topical gel delivery system to reduce the side effects by site specific targeting. The present work focused on the formulation of etodolac emulgel and the effect of natural permeation enhancers such as piperine and capsaicin.  Etodolac emulgel was prepared by emulgel method by using various excipients such as polymers as carbopol-940, propylene glycol, tween20, and span20 and with penetration enhancers such as piperine and capsaicin.  The prepared emulgel was evaluated for its properties  Further the analysis of release mechanism was carried out by fitting the drug release data to various kinetic equations like zero order, first order, higuchi’s and korssmeyer peppas equations and from the values so obtained, the best fit model were arrived at.  From the above results formulation F4 was found to be best formulation for the topical release of etodolac that complied with all the parameters.  It releases 73.79±0.98 % of drug in 8 h time. It follows the higuchi’s of drug release kinetics. Also, stability upon storage for 3 month at room temperature, where no significant change was observed in the parameters evaluated like color, consistency, pH, rheological properties, skin permeability and drug release pattern. Therefore, it was concluded that etodolac emulgel formula could be very promising topical alternative for the conventional dosage form provide sustained and prolonged delivery of drug.

Key words:Etodolac, Emulgel, Piperine, Capsaicin, Formulation, Evaluation