NOVEL CLINICAL TOXICOLOGY AND PHARMACOLOGY OF INSECTICIDES SELF POISONING

Self-poisoning from organophosphorus insecticides is a huge global health issue that kills over 100,000 people each year. It's a multi-organ disorder including the inhibition of cholinesterases and maybe other enzymes, as well as the effects of ingested solvents in excessive concentrations. Variability in lipophilicity, speed of activation, speed and effectiveness of acetylcholinesterase inhibition, and chemical groups connected to the phosphorus leads in varying poisoning onset, severity, clinical toxidrome, and case fatality among organophosphorus insecticides. The current treatment is only somewhat effective, focusing on reactivating acetylcholinesterase and counteracting the effects of too much acetylcholine on muscarinic receptors. Rapid titration of atropine during resuscitation can save lives and can be done without oxygen. The therapeutic role of oximes is unknown.Small trials of novel antidotes have been conducted, but the wide range of poisoning makes interpretation challenging. To test therapies in suitably powered research, more work is required.

Key words: Toxicology,  Pharmacology, Insecticides self poisoning, Review