Published May 25, 2022 | Version 1.0.0
Preprint Open

Genetic regulation of RNA splicing in human pancreatic islets

Creators

  • 1. Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Spain; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom
  • 2. Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Spain
  • 3. JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
  • 4. Life Sciences Department, Barcelona Supercomputing Center (BSC), 08034, Barcelona; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom
  • 5. Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain
  • 6. Lund University Diabetes Centre, Clinical Research Center, Sweden; Department of Clinical Sciences in Malmö, Sweden
  • 7. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA
  • 8. Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa, Italy
  • 9. Cell Isolation and Transplantation Center, University of Geneva, Geneva, Switzerland
  • 10. Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands; Hubrecht Institute/KNAW, Utrecht, the Netherlands
  • 11. University of Lille, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Lille (CHU Lille), Institute Pasteur Lille, U1190 -European Genomic Institute for Diabetes (EGID), F59000 Lille, France
  • 12. Diabetes Research Institute, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy

Description

Here we provide summary statistics data of splicing and gene expression QTLs (sQTLs and eQTLs, respectively) mapped in human pancreatic islets islets from 399 donors. We provide lead eQTL and sQTL associations identified at FDR 1%, all significant variant-to-gene/Junction pairs, and fine-mapped eQTLs and sQTLs. 

The full description of the study is currently available at: https://www.biorxiv.org/content/10.1101/2021.11.11.468254v1

 

 

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eQTL_CredibleSets.txt.zip

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Preprint: https://www.biorxiv.org/content/10.1101/2021.11.11.468254v1 (URL)