New Local Anaesthetics Part III. Synthesis or Some Di-5,5"-acetylamino-2',2"-arylamino-3',3'-aryl-4', 4'-thiazolidonyl-I,4-piperazines

Nine new di-5',5"-acetylamino-2',2'’-arylamino-3',3”-aryl-4',4’'-thiazolidonyl-1,4-piperazines and their hydrochlorides have been synthesised from aniline, \(p\)-chloroaniline., \(o\)-, \(m\)-, and \(p\)-toluidine, \(o\)-, and \(p\)-anisi­dine, \(o\)-and \(p\)-phenetidine respectively and their local anacethetic activity has been tested. The hydrochlorides of di-5’,5"-acetylamino- 2',2"-\(p\)-chlorophenylamino-3’,3’’-\(p\)-chlorophenyl-, 2’,2’’-\(o\)-tolyamino- 3’,3’’-\(o\)-tolyl-, 2’,2’’-\(p\)-anisylamino-3’,3’’-\(p\)-anisyl-, 2’,2’’-\(p\)-phenetylamino-3’,3’’-\(p\)-phentyl-4’,4’’-thiazolidonyl-1,4-piperazines are potent local anaesthetics among the compound reported.