Simultaneous stereo-EEG and high-density scalp EEG recordings to study the effects of intracerebral stimulation parameters
Creators
- Parmigiani, Sara1
- Mikulan, Ezequiel1
- Russo, Simone1
- Sarasso, Simone1
- Zauli, Flavia Maria1
- Rubino, Annalisa2
- Cattani, Anna3
- Fecchio, Matteo4
- Giampicolo, Davide5
- Lanzone, Jacopo6
- D'Orio, Piergiorgio2
- Del Vecchio, Maria7
- Avanzini, Pietro7
- Nobili, Lino8
- Sartori, Ivana2
- Massimini, Marcello1
- Pigorini, Andrea1
- 1. University of Milan
- 2. "Claudio Munari" Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy
- 3. Department of Mathematics & Statistics, Boston University, Boston, MA, USA
- 4. Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
- 5. Department of Neurosurgery, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
- 6. Department of Systems Medicine, Neuroscience, University of Rome Tor Vergata, Rome, Italy
- 7. Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Parma, Italy
- 8. Child Neuropsychiatry, IRCCS Istituto G. Gaslini, Genova, Italy
Description
Background
Cortico-cortical evoked potentials (CCEPs) recorded by stereo-electroencephalography (SEEG) are a valuable tool to investigate brain reactivity and effective connectivity. However, invasive recordings are spatially sparse since they depend on clinical needs. This sparsity hampers systematic comparisons across-subjects, the detection of the whole-brain effects of intracortical stimulation, as well as their relationships to the EEG responses evoked by non-invasive stimuli.
Objective
To demonstrate that CCEPs recorded by high-density electroencephalography (hd-EEG) provide additional information with respect SEEG alone and to provide an open, curated dataset to allow for further exploration of their potential.
Methods
The dataset encompasses SEEG and hd-EEG recordings simultaneously acquired during Single Pulse Electrical Stimulation (SPES) in drug-resistant epileptic patients (N = 36) in whom stimulations were delivered with different physical, geometrical, and topological parameters. Differences in CCEPs were assessed by amplitude, latency, and spectral measures.
Results
While invasively and non-invasively recorded CCEPs were generally correlated, differences in pulse duration, angle and stimulated cortical area were better captured by hd-EEG. Further, intracranial stimulation evoked site-specific hd-EEG responses that reproduced the spectral features of EEG responses to transcranial magnetic stimulation (TMS). Notably, SPES, albeit unperceived by subjects, elicited scalp responses that were up to one order of magnitude larger than the responses typically evoked by sensory stimulation in awake humans.
Conclusions
CCEPs can be simultaneously recorded with SEEG and hd-EEG and the latter provides a reliable descriptor of the effects of SPES as well as a common reference to compare the whole-brain effects of intracortical stimulation to those of non-invasive transcranial or sensory stimulations in humans.
Files
Pamigiani_Mikulan_et_al_brainstim2022.pdf
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