FORMULATION, DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERE OF LOSARTAN POTASSIUM USING NATURAL POLYMER

Floating microspheres of Losartan potassium was prepared solvent evaporation method with an aim of increasing the gastric residence time and for controlled release. HPMC, EC and Sodium alginate, polymeric mixture were used as polymers. The present work was aimed to control drug delivery and alter the pharmacokinetics and pharmacodynamics of Losartan potassium, to ensure safety, improve efficacy, therapeutic action as well as patient compliance.  Percentage yield of different formulation was determined by weighing the microspheres after drying.  The percentage yield of different formulation was in range of 68.65±0.15–80.46±0.42%. The maximum Percentage Yield was found in formulation F4, 80.46±0.42as compare to all formulation. The drug entrapment efficacies of different formulations were in range of 59.25±0.24-74.55±0.64%w/w. The maximum percentage drug entrapment was found in formulation F4 (74.55±0.64% w/w). The maximum Percentage Yield, Drug Entrapment, Percentage Buoyancy and floating lag time was found to be formulation F4 in floating microsphere. The optimized formulation of F4 both batches subjected to further studies. The results of measurement of mean particle size of optimized formulation F4 of floating microsphere was found to be 331.6 nm. Hydrophilic matrix of HPMC and EC alone could not control the release of drug effectively for 12 hours and the release pattern was satisfactory. The use of ec and Sod Alginate along with HPMC proved to show better retarding ability which was clearly seen from the results.

Key words: Losartan Potassium, HPMC, EC,  Sodium alginate, Formulation, Evaluation.