DISINTEGRATING AGENTS THE BACKBONE OF MOUTH DISSOLVING TABLETS

Mouth dissolving tablets (MDT) show the quick onset of action and are currently in demand because of several advantages like palatability and a pleasant mouthfeel. MDT can be consumed without water and shows effective action in a few minutes. MDT is advantageous particularly in all groups including pediatric, mentally ill, and geriatric patients who are unable to swallow conventional tablets and capsules. Disintegrants has a significant role in quick disintegration thereby enhancing its efficacy. In presence of super disintegrants, the tablet dissolves within 5-30 seconds range. Disintegrants are classified mainly into three categories natural, synthetic, and coprocessed. Various super disintegrants e.g. croscarmellose sodium, crospovidone, and sodium starch glycolate are added in MDT for faster dissolution. Various superdisintegrants are available in the market like ludiflash, fmelt, cellactose 80, microcelac 100 and avicel DG, etc

The review describes the various formulation aspects, techniques developed for MDTs, and super disintegrants used, along with evaluation tests, drugs, marketed formulation, and various excipients used for R&D.

Keywords: ODT, Mouth dissolving tablets, flash dose tablets, mouth disintegrating tablets, oral disintegrating tablets, super disintegrants