Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging
Creators
- Carregal‐Romero, S
- Miguel‐Coello, AB
- Martínez‐Parra, L
- Martí‐Mateo, Y
- Hernansanz‐Agustín, P
- Fernández‐Afonso, Y
- Plaza‐García, S
- Gutiérrez, L
- Muñoz‐Hernández, MdM
- Carrillo‐Romero, J
- Piñol‐Cancer, M
- Lecante, P
- Blasco‐Iturri, Z
- Fadón, L
- Almansa‐García, AC
- Möller, M
- Otaegui, D
- Enríquez, JA
- Groult, H
- Ruíz‐Cabello, J.
Description
Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost-efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (MnxFe3-xO4, 0.1 <= x <= 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual-mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase-mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications.
Files
Small_carregal.pdf
Files
(1.9 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:0130af8676a67bec03d740c31a545f8f
|
1.9 MB | Preview Download |