Coronavirus Disease Research Community - COVID-19
Published March 22, 2022 | Version v1
Journal article Open

Correlates of Protection Against SARS CoV-2 Infection and Covid 19 Disease

Creators

  • 1. Great Ormond St. Institute of Child Health
  • 2. Ragon Institute
  • 3. La Jolla Institute of Virology
  • 4. university of Pennsylvania

Description

Antibodies against epitopes in S1 of SARS-2 coronavirus give the most accurate correlate of protection against infection. Measurement of those antibodies by neutralization or binding assays have predictive value.  However, the protective functions of antibodies are multiple, including Fc effector functions.  The role of cellular responses include CD4+ T cells and their augmentation of antibodies, as well as CD8+ T cells that control viral replication.  More information is needed regarding mucosal responses.

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