Solvent Effect on Amide Hydrolysis. III--Kinetics of Formamide Hydrolysis in isoPropanol-Water Mixtures

Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

Manuscript received 13 April 1977, accepted. 1 August 1977

Solvent effects on the acid and base hydrolysis of formamide were investigated in isopropanol-water mixtures, up to 75.06 wt % of the alcohol, at the temperature range 25-60º. Both reactions are retarded by increasing the concentration of isopropanol,
but in case of the base hydrolysis the rate increases on further progressive addition of the alcohol passing through a minimum at about 34 wt % of isopropanol. Temperature, dielectric constant,· solvent composition, activation parameters, acidity function and
medium effects on reaction rates and mechanisms are briefly discussed.