Decarboxylation and Deamination of Amino Acids by N-Bromo-N-sodio-p-toluenesulphonamide in Perchloric Acid Medium. A Kinetic Study

Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri-574-199

Manuscript received 26 December 1985, revised 14 March 1988, accepted 17 March 1988

Kinetics of decarboxylation and deamination of amino acids by N-bromo-N-sodio-p-toluenesulphonamide have been Investigated In perchloric acid medium. The reaction followed first order kinetics each In [oxidant] and [substrate] and inverse first order in [H⁺]. Variation in ionic strength of the medium and addition of the reaction product, p-toluenesulphonamide had no effect on the rate of reaction. The effect of variation In dielectric constant of the medium on the rate has also been investigated. The activation parameters have been computed from the Arrhenius plots. A suitable mechanism consistent with observed results has been proposed. Validity of Taft equation has also been tested.