Synthesis and Antimicrobial Activities of some lsoxazolo-[5',4' : 4,5]pyrimido[6,1-c]1,2,4-triazine Derivatives

Department of Chemistry, Karnatak University, Dharwad-580 003

Manuscript received 25 November 1987, revised 23 March 1988, accepted 6 April 1988

4-Hydrazino-3,6-disubstituted isoxazolo[5,4-d]pyrimidines (3a- i), when treated with 1-chloro-2-propanone yielded (3,6-disubstituted-isoxazolo[5,4-d]pyrimidine-4-yl)hydrazones of 1-chloro-2-propanone ( 4a- i), which on cyclisation produced the title compounds, viz 6,10-disubstituted-3-methyl-4H-isoxazolo[5',4': 4, 5]pyrimido[6,1-c) 1,2,4-triazines (5a- i). Structures of new compounds have been established by their spectral and elemental analyses. They have been subjected to in vitro antibacterial screening against five pathogenic strains aad antifungal testing agaiast three fungi; many compounds exhibited promising results.