SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-{4-[5-(SUBSTITUTED PHENYL)ISOXAZOL-3-YL]PHENYL}-2-(4-HYDROXYPHENYL)-1,3-THIAZOLIDIN-4-ONE"

Heterocyclic Compounds have so far been synthesized mainly due to the wide range of biological activities. Isoxazoles plays an important role in biological field. From these reviews we synthesized a new series of 3-{4-[5-(substititedphenyll) isoxazol-3-yl]phenyl}-2-(4-hydroxyphenyl)-1,3-thiazolidin-4-one derived from 3-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-(4-hydroxyphenyl)-1,3-thiazolidin-4-one and hydroxylamine hydrochloride. The title compounds were characterized by element analysis, IR, NMR and spectral data. All the compounds were tested for their antibacterial and antifungal activities by Cup Borer method.

Keywords: Isoxazoles, IR, NMR, Cup Borer method.