Adaptive Cellular Immunity against African Swine Fever Virus Infections

African swine fever virus (ASFV) remains a threat to global pig populations. Infections
with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild
pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by
the infection as well. The complex responses remain not well understood, and, consequently, there
is no commercially available vaccine. Here, we review the current knowledge about the induction
of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected
animals, recent efforts in vaccine research, and T cell epitopes present in ASFV.