FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET DILTIAZEM HYDROCHLORIDE

New era of novel drug delivery system oriented towards increasing safety and efficacy of existing drug molecule through novel concepts like buccal drug delivery system. mucoadhesive buccal systems have carved a niche amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. Buccal mucoadhesive tablet containing diltiazem HCl was prepared for treatment of hypertension. Buccal mucoadhesive tablet of diltiazem HCl were prepared by direct compression methods and blend was evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The tablets were prepared by using carbopol, hydroxy propyl methyl cellulose (HPMC), and sodium alginate as mucoadhesive polymers in different concentration along with magnesium stearate and talc. Total six formulations were prepared and evaluated for hardness, friability, weight variation, content uniformity, wetting time, water absorption ratio, disintegration time and invitro drug release. In-vitro dissolution studies are performed by using phosphate buffer pH 6.8 at 75 rpm by paddle method. Formulation F5 showed maximum release of 99.78% in 12hours. Formulation F5 showed maximum swelling index of 106.65 after 12hours. Formulation F5 follows Korsmeyer-Peppas order drug release. FTIR studies show no evidence on interaction between drug and polymers. The results indicate that suitable mucoadhesive buccal tablets with desired properties could be prepared.

Keywords: Diltiazem hydrochloride, carbopol, hydroxy propyl methyl cellulose, Buccal mucoadhesive tablet