Somatic mutations alter the differentiation outcomes of iPSC-derived neurons (Metadata and AnnData/H5AD files)
Creators
- 1. UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Contributors
Project managers:
Researchers:
- 1. Open Targets, Wellcome Genome Campus, Cambridge, UK
- 2. Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK
- 3. UCL Great Ormond Street Institute of Child Health, University College London, London, UK
- 4. Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Finland
Description
Data S1: Metadata information for the 828,937 processed cells from the DN dataset: donor identity, cell type annotation, pool identifier, 10x sample, time point and replicate information. Related to STAR Methods: Reanalysis of pooled single-cell data (DA).
Data S2-S4: AnnData/H5AD files containing the single-cell gene expression matrices and the metadata for day 11, day 30 and day 52, respectively. The gene expression is normalised and log-transformed, but not scaled. md5 files are also included. Related to STAR Methods: DE analysis between failed and successful lines.
#File names:
File-Data S1: suppData1.RDS
File-Data S2: allpools.scanpy.D11.wMetaClustUmapGraph.exprLogNormNotScaled_notKO.h5ad
File-Data S3: allpools.scanpy.D30.wMetaClustUmapGraph.exprLogNormNotScaled_notKO.h5ad
File-Data S4: allpools.scanpy.D52.wMetaClustUmapGraph.exprLogNormNotScaled_notKO.h5ad
Files
Files
(18.8 GB)
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md5:ff760f4c94ec790ffbdb78cfa15490fd
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6.0 GB | Download |
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md5:021fe314c0aebde9a6b17bef913e4a83
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106 Bytes | Download |
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md5:8e02c1caba6e1090a9939faf9cfa5c4b
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5.8 GB | Download |
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md5:5c08cedda4fc185f74349090e8cc7aa8
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106 Bytes | Download |
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md5:393c9f3cc7d3ffd98912f292b83c3b01
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7.1 GB | Download |
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md5:edde6b172628ceb54447d877f11a1799
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106 Bytes | Download |
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md5:bf56a3a5019d994e17602b6430ac2ec3
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8.5 MB | Download |
Additional details
References
- Puigdevall, P. et al. Effects of somatic mutations on cellular differentiation in iPSC models of neurodevelopment. bioRxiv (2022) doi:10.1101/2022.03.04.482992.