Journal article Open Access
Mid-trimester maternal serum AFP levels in predicting adverse pregnancy outcome
Gkogkos Panagiotis;
Androutsopoulos Georgios;
Vassilakos Pavlos;
Panayiotakis Georgios;
Kourounis Georgios;
Decavalas Georgios
Objective: In our prospective study, we investigated the association between mid-trimester maternal serum AFP (ms-AFP) levels and adverse pregnancy outcome, in the South-Western Greek population.
Materials and Methods: 110 healthy Greek women with spontaneous pregnancies, investigated for ms-AFP levels between 13th-24th weeks of gestation and followed for adverse pregnancy outcome. AFP levels > 2.0 multiples of the median value for gestation, were considered abnormal. Statistical analysis was performed by Pearson’s chi-square test.
Results: Elevated ms-AFP levels were detected in a total of 27 from the 110 women studied (24.5%). Among them, only 4 women (14.8%) developed pregnancy complications.
Conclusion: Multiparameter testing of placental function in the mid-trimester (uterine artery Doppler, placental morphology and ms-AFP screening) may allow us to identify women with increased risk to develop severe placental insufficiency and pregnancy complications.
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- Publication date:
- September 1, 2008
- DOI:
-
- Keyword(s):
- maternal serum AFP levels adverse pregnancy outcome
- Published in:
- Clin Exp Obstet Gynecol: 35 pp. 208-210 (3).
- Related identifiers:
- Identical to
- https://www.ncbi.nlm.nih.gov/pubmed/18754295 (Journal article)
- License (for files):
- Creative Commons Attribution 4.0 International