Clinical Outcome and Striatal Dopaminergic Function After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus
Creators
- 1. IRCCS Mondino Foundation, Pavia (Italy)
- 2. Istituti Clinici Scientifici Maugeri, Pavia (Italy)
- 3. IRCCS Mondino Foundation, Pavia (Italy); Julius-Maximilians-Universität Würzburg (Germany)
- 4. Julius-Maximilians-Universität Würzburg (Germany)
- 5. University of Pisa (Italy)
- 6. University Health Network University of Toronto (Canada)
Description
The dataset contains clinical and instrumental data collected from 102 patients with idiopathic normal pressure hydrocephalus (iNPH) showing neither significant levodopa response nor signs of atypical parkinsonism. Clinical features included total and subitem scores of the MDS-UPDRS III, and total and subitem scores of the iNPH rating scale.
MRI findings included Evans’ index, flow void sign, and DESH. At baseline, 92 iNPH patients underwent FP-CIT SPECT, which was repeated two years later in 58 cases. SPECT findings were evaluated as specific binding ratio (SBR) at the level of putamen and caudate nucles, bilaterally.
Fifty-nine patients underwent shunt surgery. Both cohorts of patients who did or did not undergo shunt surgery were clinically followed up one and two years after baseline. Clinical assessment at follow-up included total and subitem scores of the MDS-UPDRS III, and total and subitem scores of the iNPH rating scale.
Notes
Files
Restricted
The record is publicly accessible, but files are restricted to users with access.
Request access
If you would like to request access to these files, please fill out the form below.
You need to satisfy these conditions in order for this request to be accepted:
This data set of raw data is accessible under request by writing to the Scientific Direction of the IRCCS Mondino Foundation (dirsci@mondino.it) specifying:
- own affiliation;
- how one intends to use data.
You are currently not logged in. Do you have an account? Log in here
Additional details
Related works
- Is published in
- Journal article: 10.1212/WNL.0000000000012064 (DOI)