Journal article Open Access

Polymeric 19F MRI Contrast Agents Prepared by Ring-Opening Metathesis Polymerization/Dihydroxylation

Tennie, Iris K.; Kilbinger

The capability of ring-opening metathesis polymerization (ROMP) to efficiently incorporate bulky monomers and conserve olefin bonds during polymerization was exploited to design water-soluble fluoropolymers, which were evaluated as potential quantitative 19F magnetic resonance imaging (MRI) contrast agents. The fluoromonomeric units comprised 3, 6, 9, or 18 magnetically equivalent fluorine atoms. Aqueous solubility was achieved through dihydroxylation of the partially unsaturated polymeric backbone and by tetraethylene glycol (TEG)-based linker incorporation, ammonium quaternization, or copolymerization.

Files (605.4 kB)
Name Size
Manuscript.pdf
md5:de776975aea4bcf36b39811a3b9e7f27
605.4 kB Download
16
24
views
downloads
Views 16
Downloads 24
Data volume 14.5 MB
Unique views 13
Unique downloads 23

Share

Cite as