Published June 15, 2014 | Version v1
Journal article Open

INSULIN RESISTANCE IN COWS DURING DRY PERIOD AND EARLY LACTATION

Creators

  • 1. Department of Veterinary medicine, Faculty of Agriculture, University of Novi Sad, Trg D.Obradovica 8, Novi Sad, Serbia

Description

Insulin resistance is pathophisiological term defined as change in insulin responsiveness (insulin response to glucose) or insulin sensitivity (tissue response to insulin) or both. The aim of this study was to investigate insulin resistance in dairy cows during dry period and early lactation, and determine influence of insulin, glucose and NEFA to RQUICKI index of insulin resistance. Cows in early lactation showed lower concentration of glucose and insulin and higher concentration of NEFA compared to cows in dry period. Insulin:glucose index are 2.5 in dry period and 2.05 in early lactation. RQUICKI index was lower during early lactation. Determination of RQUICKI value using a concentration of glucose, insulin and NEFA was correct in 78.9% in dry period and 84.5% in early lactation. During dry period insulin and glucose showed significant influence to RQUICKI value (negative correlation), but there was found absence of NEFA influences. However, NEFA only showed significant influences to RQUICKI in early lactation (negative correlation). Insulin and glucose determined RQUICKI in 56% from 78.9% of whole model, but in early lactation NEFA determined 32% from 84.5%. Higher glucose concentration means higher insulin response in dry period with consequently poor insulin binding and glucose transport. In this condition it is need higher concentration of insulin to neutralize same concentration of glucose. Therefore, found higher insulin:glucose ration was found in dry period in relation to early lactation. Insulin resistance
is more intense in early lactation compared to dry period. Based on metabolic change insulin resistance in dry period is consequence of decreased insulin sensitivity of peripheral tissue with compensatory increased insulin:glucose ration. During early lactation there is decrease insulin and glucose concentration with lower insulin response to glucose. Absence of insulin increases lipid mobilization which determined insulin resistance level.

Files

12 CINCOVIĆ i BELIĆ 2014 Vol. 63, No. 1-2 pp. 92-97.pdf

Files (584.5 kB)

Additional details

References

  • BALOGH, O., SZEPES, O., KOVACS, K., KLUCSAR, M., REICZIGEL, J., ALCAZAR J.A., KERESZTES, M., FEBEL, H., BARTYIK, J., FEKETE, S.G., FESUS, L., HUSZENICZA G.: Interrelationship of growth hormone AluI polymorphysm, insulin resistance, milk production and reproductive performance in Holstein-Friesian cows. Veterinarni Medicina, 53(11)604-616, 2008.
  • BJERRE-HARPØTH, V., FRIGGENS, N.C., THORUP, V.M., LARSEN, T., DAMGAARD, B.M., INGVARSTEN, K.L., MOYES, K.M.: Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation. J. Dairy Sci., 95:2362–2380, 2012.
  • CARRA, M., AL-TRAD, B., PENNER, G.B., WITTEK, T., GABEL, G., FÜR, M., ASCHENBACH, J.R.: Intravenous infusions of glucose stimulate key lipogenic enzymes in adipose tissue of dairy cows in a dose-dependent manner. J. Dairy Sci., 96(7)4299-4309, 2013.
  • CINCOVIĆ, M.R., BELIĆ, B., RADOJIČIĆ, B., HRISTOV, S., ĐOKOVIĆ, R.: Influence of lipolysis and ketogenesis to metabolic and hematological parameters in dairy cows during periparturient period. Acta veterinaria (Beograd), 62(4)429-444, 2012.
  • CINCOVIĆ, M.R., BELIĆ, B., VIDOVIĆ B., KRČMAR, LJ.: Reference values and frequency distribution of metabolic parameters in cows during lactation and in pregnancy. Contemporary agriculture, 60(1-2)175-182, 2011.
  • CINCOVIĆ M.R.: Upotreba indikatora insulinske rezistenciej u proceni metaboličkog statusa krava u ranoj laktaciji. Specijalistički rad. Fakultet veterinarske medicine, Beograd, 2013.
  • DJOKOVIĆ R. CINCOVIĆ, M., KURCUBIC, V., PETROVIĆ, M., LALOVIĆ, M., JAŠOVIĆ, B., STANIMIROVIĆ, Z.: Endocrine and Metabolic Status of Dairy Cows during Transition Period. Thai J. Vet. Med., 44(1)59-66, 2014.
  • GROSS, J., VAN DORLAND, H.A., BRUCKMAIER, R.M., SCHWARTZ, F.J.: Performance and metabolic profile of dairy cows during a lactational and deliberately induced negative energy balance with subsequent realimentation. J. Dairy Sci., 94:1820-1830, 2011.
  • GRUMMER, R.R., RASTANI, R.R.: When should lactating dairy cows reach positive balance? Prof. Anim. Scientistm 19:197-203, 2003.
  • HAARSTRICH, D.: Evaluation of surrogate indices of insulin sensitivity by means of hyperinsulinemiceuglycemic glucose clamps in dairy cows; u: Insulinsensitivität und Insulinresponse nach einer Langzeit-Supplementation von konjugierten Linolsäuren bei laktierenden Milchkühen. Inaugural disertation. Tierärztliche Hochschule Hannover, 2011.
  • HACHENBERG, S., WEINKAUF, C., HISS S., SAUERWEIN, H.: Evaluation of classification modes potentially suitable to identify metabolic stress in healthy dairy cows during the peripartal period. J.Anim. Sci., 85:1923-1932, 2007.
  • HAYIRLI, A.: The role of exogenous insulin in the complex of hepatic lipidosis and ketosis associated with insulin resistance phenomenon in postpartum dairy cattle. Vet. Res. Commun., 30:749–774, 2006.
  • HOLTENIUS, P., HOLTENIUS, K.: A model to estimate insulin sensitivity in dairy cows. Acta Veterinaria Scandinavica, 49:29-31, 2007.
  • JOVANOVIĆ, M. J, STAMATOVIĆ, S, ŠAMANC, H. et al.: Prilog proučavanju metaboličkog profila krava u laktaciji. Vet. Glasnik, 41(6)449-454, 1987.
  • KERESZTES M, FAIGL, V., KULCSÁR, M., BALOGH, O., FÖLDY, J., FÉBEL, H., CHILLARD, Y., HUSZENICZA, G.: Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis. Domest Anim Endocrinol., 37(4)250-261, 2009.
  • KESSEL, S., STROEHL, M., MEYER, H.H.D., HISS, S., SAUERWEIN, H., SCHWARZ, F.J., BRUCKMAIER, R.M.: Individual variability in physiological adaptation to metabolic stress during early lactation in dairy cows kept under equal conditions. J. Anim. Sci., 86:2903-2912, 2008.
  • KOVAČEVIĆ, M., ŠAMANC, H., DAMJANOVIĆ, Z., KIŠARČIĆ, S.: Koncentracija triglicerida i NEFA u krvi krava u visokom graviditetu i posle teljenja. Savremena poljoprivreda, 51(3-4)111-113, 2002.
  • KRNIĆ, J., PAŠIĆ-JUHAS, E., KANAČKI, Z., HODŽIĆ, A., HAMAMDŽIĆ, M.: Uticaj nepovoljnih uslova ishrane na karakteristike metaboličkog profila krava. Savremena poljoproverda, 55(3-4)136-142, 2006.
  • KUNZ, P.L., BLUM, J.W., HART, I.C., BICKEL, H., LANDIS J.: Effects of different energy intakes before and after calving on food intake, performance and blood hormones and metabolites in dairy cows. Animal Production, 40(2)219-231, 1985.
  • LI, Y., DING, L., HASSAN, W., ABDELKADER, D., SHANG, J.: Adipokines and Hepatic Insulin Resistance. Journal of Diabetes Research, Article ID 170532, 8 pages, 2013.
  • LOPATNICU, E.-R., RONZONI, A.: Metabolic syndrome in humans and in cows: a review. Lucrări Ştiinţifice Medicină Veterinară, XLVI(4)100-109, 2013.
  • OSPINA, P.A., NYDAM, D.V., STOKOL, T., OVERTON, T.R.: Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J. Dairy Sci., 93(20)546-554, 2010.
  • PRODANOVIĆ, R., KIROVSKI, D., VUJANAC, I., ĐURIĆ, M., KORIĆANAC, G., VRANJEŠ-ĐURIĆ, S., IGNJATOVIĆ, M., ŠAMANC, H.: Insulin responses to acute glucose infusion in Buša and Holstein-friesian cattle breed during the periparturient period: comparative study. Acta veterinaria, 63(4)373-384, 2013.
  • WATHES, D.C., CHENG, Z., BOURNE, N., TAYLOR, V.J., COFFEY, M.P., BROTHERSTONE, S.: Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domestic Animal Endocrinology, 33(2)203-225, 2007.