REVIEW STUDY: POLYMORPHISM IDENTIFIED IN SEPSIS INDUCED ACUTE KIDNEY INJURY

Background: Sepsis-induced acute kidney injury (S-AKI) is a typical complexity in hospitalized and basically sick patients, which expands the danger of creating constant comorbidities and is related with incredibly high mortality.

Objective: This study aimed at providing an update on polymorphism identified in sepsis induced acute kidney injury.

Methods: The online database was searched then the articles were evaluated then all the eligible English studies during the last 10years were included in the study.

Results:there were 31 studies included focusing on the association between gene polymorphism and AKI induced by sepsis in which 13 gene polymorphisms were studied.

Conclusion: The genetic structure of the individuals can impact the vulnerability and severity of AKI. Most of the gene polymorphisms can’t induce AKI alone but can act with other genetic disturbances and depends on the health state of patients and their compromised state. Thus, AkI is supposed to be influenced by genetic factors with different pathological pathways.

Keywords: polymorphism, sepsis induced acute kidney injury