Synthesis and biological evaluation of 3-aryl-2-(2-chloro-7- methoxyquinolin-3-yl)-4-thiazolidinones

Department of Chemistry, Saurashtra University, Rajkot-360 005, India

Manuscript received 30 September 1999, revised 25 July 2000, accepted 22 September 2000

3-Aryl-2-(2-chloro-7-methoxyquinolin-3-yI)-4-thiazolidinones (3a-m, 4a-m) have been synthesised by the condensation of thioglycolic acid/thiolactic acid with N-aryl-(2-chloro-7-methoxyquinolin-3-yl) azomethine (2a-m) which in turn are prepared from arylamine and 2-chloro-7-methoxyquinoline-3-carboxaldehyde (1). The products have been evaluated for their antibacterial and antifungal activities