Constituents of the Annonaceae species Miliusa velutina and Desmos longiflorus

Department of Chemistry, University of Glasgow, Glasgow Gl2 8QQ, Scotland, U.K.

Manuscript received 13 November 2003

Extraction of the stem bark of Miliusa velutina afforded miliusolide (1), an enediyne-y-lactone derivative, and its dihydroderivative (4), together with two other fatty acid-derived lactones. The stem bark of Desmos longiflorus yielded a triterpenoid, 15α-hydroxy-24-methylene-7,9(11)-lanostadien-3-one (7), three modified flavonoid derivatives, desmoflorin (8), 4-O- acetyldesmoflorin (9) and 4-O-epidesmoflorin (10), and an alkaloid, 3-hydroxy-2-methoxy-9,19-methylenedioxytetrahydroprotoberberine (11) (tetrahydrogroenlandicine).