Published January 11, 2022
| Version 1
Dataset
Open
Ultrafast imaging recordings from the axon initial segment of neocortical layer-5 pyramidal neurons.
Contributors
Data collectors:
- 1. Univ. Grenoble Alpes, CNRS, LIPhy, F-38000 Grenoble, France
Description
This dataset contains imaging and whole-cell electrophysiological recordings from neocortical layer-5 pyramidal neuron from brain slices of the mouse.
Electrophysiological recordings (at 20 kHz) are from the soma. Imaging data (10 kHz) are from lines along the axon initial segment (distal>proximal) with 500 nm pixel resolution. These correspond to:
- Sodium imaging (Figures 1 and S6).
- Voltage imaging (Figures 2,4,5,S4,S7)
- Calcium imaging (Figures 3,S3,S8).
This dataset is used in the paper available online:
Filipis L, Blömer LA, Montnach J, De Waard M, Canepari M. Nav1.2 and BK channels interaction shapes the action potential in the axon initial segment. bioRxiv, 2022. doi: 10.1101/2022.04.12.488116.
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Additional details
Funding
- Agence Nationale de la Recherche
- OptChemCom - Integrated optical, photochemical and computational technologies to study the physiological synergy of different ion channels ANR-18-CE19-0024
- Agence Nationale de la Recherche
- ICST - Canaux ioniques d'intérêt thérapeutique ANR-11-LABX-0015
References
- Filipis et al. (2022) BiorXiv doi: 10.1101/2022.04.12.488116