Synthesis of some new cyanopyrans and cyanopyridines and their biological activities

Department of Chemistry, Saurashtra University, Rajkot-360 005, India

E-mail : drhsjosh i@ yahoo.com      Fax: 91-0281-2578512

Manuscript received 31 January 2003, revised 12 May 2003, accepted 24 July 2003

Chalcones 1-aryl-3-m-chlorophenyl-2-propene-1-ones, 1a-j, underwent Michael addition on renuxing with malononitrile in the presence of pyridine and ammonium acetate in ethanol to give compounds 2-amino-3-cyano-4-(3'-chlorophenyl)-6-(4-phenyl)-pyran, 2a-j and 2-amino-3-cyano-4-(3'-chlorophenyl)-6-(4-phenyl)-pyridine, 3a-j, respectively. The newly synthesized compounds have been screened for their anticancer, antitubercular and antimicrobial activities.