Published January 16, 2017
| Version v1
Journal article
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Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media
Description
Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.
Notes
This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no 604434 (PneumoNP). This research was also supported by the Departamento de Desarrollo Económico y Competitividad of the Basque Government, under the Elkartek 2015 program, project biomagune 2015, ref. KK- 2015/0000088, and by the Spanish Ministry of Economy and Competitiveness, project MAT2013-48169-R. We thank Idoia Tolosa for technical support. Samir Safi (Malvern Instruments Ltd) and Mariano Barrado (UPV-EHU) are acknowledged for helpful assistance with Viscosizer TD and TEM, respectively.Competitiveness, project MAT2013-48169-R. We thank Idoia Tolosa for technical support. Samir Safi (Malvern Instruments Ltd) and Mariano Barrado (UPV-EHU) are acknowledged for helpful assistance with Viscosizer TD and TEM, respectively.
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