Synthesis of some thiosemicarbazone and oxirane derivatives as potent antitubercular agents

Department of Chemistry, Saurashtra University, Rajkot-360 005, India
E-mail : drhsjoshi@yahoo.com                            Fax: 91-281-2578512
Manuscript received 13 August 2004, revised 7 July 2005, accepted 14 July 2005

Condensation of thiosemicarbazide with 1-aryl-3-(3'-chlorophenyl)-2-propene-1-ones (la-j) afforded corresponding 4-α( 3'-chlorostyryl)-benzylidene-thiosemicarbazones (2a-j) and the compounds (1a-j) on reaction with alkaline H₂O₂ gave 3-(3' -chlorophenyl)-2-substituted benzoyl oxiranes (3a-j). All the compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H₃₇Rv).