Synthesis, characterization and antimicrobial study of substituted bis-[1 ,3,4]-oxadiazole, bis-[1 ,3,4]-thiadiazole and bis-[1,2,4]-triazole derivatives

Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001,
Maharashtra, India
E-mail : pradip22209l@yahoo.co.in
Postgraduate Department of Chemistry, Shri Shivaji Science College, Amravati-444 603, Maharashtra, India
Manuscript received 29 April 2008, accepted 16 July 2008

Series of compounds 1,4-bis-(2-aryl/alky1-amino-[1,3,4]-oxadiazol-5-yI)-benzenes, 1,4-bis-(2-aryl/alkyl-amino[
1,3,4]-thiadiazol-5-yl)-benzenes and 1,4-bis-(3-mercapto-4-aryl/alkyl-[1,2,4]-triazol-5-yl)-benzenes have been synthesized
by the oxidative cyclization of di-(N-aryl/alkyl thiocarbamido) terephthalamides using alkaline ethanolic solution of iodine
containing potassium iodide, ortho-phosphoric acid and aqueous potassium hydroxide solution respectively. These
compounds on acetylation afforded his-acetyl derivatives, on benzoylation afforded his-benzoyl derivatives and on reaction
with ethyl iodide afforded bis-ethylmercapto derivatives respectively. These compounds have been assayed for their
antimicrobial activity against gram-positive as well as gram-negative microorganisms.