Published February 9, 2022 | Version v1
Dataset Open

Dataset - The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

Creators

  • 1. Vivek V.
  • 2. Kunal
  • 3. Théo
  • 4. Anaëlle
  • 5. Romain
  • 6. Florence
  • 7. Muhammet Fatih
  • 8. Andrea

Description

Dataset corresponding to the LoC studies in the manuscript titled The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. The following data are included:

BioEM.zip: Volumetric electron microscopy - representative movies of volumetric scans of fields of view of the vascular face of uninfected control and SARS-CoV-2 infected LoCs. Blender file containing reconstruction of mitochondria.

Cleaved-caspase3.zip: Imaris files for analysis of 3D stacks from two- and three-component LoCs immunostained for cleaved-caspase 3.

IFN beta.zip: Imaris files for analysis of 3D stacks from two- and three-component LoCs immunostained for IFN beta.

PhosphoSTING.zip: Imaris files for analysis of 3D stacks from two component LoCs immunostained for phosphoSTING.

Proteomics_R_code.Rmd: Annotated custom scripts in R for the analysis of the proteomics data.

Notes

VVT received support from a grant from the Novartis Foundation for Medical-Biological Research (grant no: 20C240).

Files

BioEM.zip

Files (96.8 GB)

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Additional details

Funding

cGAS-STING-mediated self-DNA sensing in COVID-19 immunopathology 4078P0_198470
Swiss National Science Foundation