Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum
Creators
- 1. Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, 43125 Parma, Italy
- 2. MANIBUS Laboratory, Department of Psychology, University of Turin, 10124 Turin, Italy
- 3. Dipartimento di Scienze Biomediche e Cliniche 'L. Sacco,' Universita` degli Studi di Milano, 20157 Milano, Italy
- 4. Centro per la Chirurgia dell'Epilessia 'Claudio Munari,' Ospedale Ca' Granda—Niguarda, 20162 Milano, Italy
- 5. Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, 43125 Parma, Italy, Centro per la Chirurgia dell'Epilessia 'Claudio Munari,' Ospedale Ca' Granda—Niguarda, 20162 Milano, Italy
- 6. Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, 43125 Parma, Italy, Dipartimento di Medicina e Chirurgia, Universita` degli Studi di Parma, 43125 Parma, Italy
- 7. MANIBUS Laboratory, Department of Psychology, University of Turin, 10124 Turin, Italy, Neuroscience Institute of Turin (NIT), 10124 Turin, Italy
Description
Although clinical neuroscience and the neuroscience of consciousness have long sought mechanistic explanations
of tactile-awareness disorders, mechanistic insights are rare, mainly because of the difficulty of depicting the fine-
grained neural dynamics underlying somatosensory processes.
Here, we combined the stereo-EEG responses to somatosensory stimulation with the lesion mapping of patients
with a tactile-awareness disorder, namely tactile extinction.
Whereas stereo-EEG responses present different temporal patterns, including early/phasic and long-lasting/tonic
activities, tactile-extinction lesion mapping co-localizes only with the latter. Overlaps are limited to the posterior
part of the perisylvian regions, suggesting that tonic activities may play a role in sustaining tactile awareness. To
assess this hypothesis further, we correlated the prevalence of tonic responses with the tactile-extinction lesion
mapping, showing that they follow the same topographical gradient. Finally, in parallel with the notion that visuo-
tactile stimulation improves detection in tactile-extinction patients, we demonstrated an enhancement of tonic
responses to visuotactile stimuli, with a strong voxel-wise correlation with the lesion mapping.
The combination of these results establishes tonic responses in the parietal operculum as the ideal neural correl-
ate of tactile awareness.
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