PULSATILE DRUG DELIVERY SYSTEM- A REVIEW

Pulsatile-release delivery systems are gaining popularity for the development of medications for which conventional controlled-release systems with a continuous release are ineffective. Pulsatile Drug Delivery Systems are gaining popularity because they deliver the drug to the appropriate place, at the right time, and in the right amount, ensuring spatial and temporal delivery while also boosting patient compliance. Humans have endogenous circadian rhythms that are controlled by the body's master circadian clock. The drug release profile of the product is sigmoidal, with a period of no release (lag time) followed by quick and total drug release. are not consistent, but change through time. Despite the fact that much drug delivery research has focused on constant drug release rates due to the limitations of delivering drugs according to disease rhythmicity, clinical studies show that the magnitude of rhythmic differences can be a significant predictor of when the most morbid and mortal events will occur during a 24-hour period.

The range of systems and approaches that can be used to deliver therapeutics is growing and advancing at an incredible rate, so learning about the advances in drug delivery has important implications for anyone working in health care and related sectors. Currently, Pulsatile drug delivery is gaining cumulative attention as it offers a more sophisticated approach to the traditional sustained drug delivery, a constant amount of drug released per unit time or constant blood levels. Pulsatile drug delivery aims to release drugs on a programmed pattern i.e.: at appropriate time and/or at appropriate site of action