The determination of pharmaceutically important ibuprofen by non-aqueous potentiometric titration method

Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001,Maharashtra, India

E-mail : pradip22209l@yahoo.co.in

Manuscript received online 05 December 2012, revised 26 December 2012, accepted 30 December 2012

The determination of pharmaceutically important ibuprofen by non-aqueous potentiometric titration method using isopropyl alcohol as the solvent and KOH in isopropyl alcohol as the titrant has been established. The study of effect of solvent and concentration on potentiometric determination of ibuprofen has been carried out followed by the estimation of ibuprofen in single component tablets. The titrations were carried out using a pair of glass and calomel electrode. The method was found to be precise for assay of ibuprofen and results obtained are comparable with those obtained by I.P. method.